First of all, listen to the old guys, they know stuff! They've already made the mistakes your about to make because they didn't listen to the old guys when they were younger, and yet, they somehow managed to survive to be old guys. This is why old guys are smarter; they have more experience. They also get crotchety from having to deal with younger people who don't listen.
I don't know what you consider "significant', but all things being equal, the round out of a 24" barrel will be a little slower than one that is 16." A .22 round will gain its maximum velocity somewhere between 16" to 19" of barrel length. After that approximate barrel length the expanding gas from the powder burn can't keep up with the increasing volume of the rifle bore behind the bullet, so the pressure drops, and the bullet begins to slow down due to bore friction. This reduction in velocity is a good thing, Why? A slower bullet, travelling below the speed of sound produces less aerodynamic drag than a bullet going faster. A slower bullet is less effected by wind drift than a faster bullet.
The speed of sound is not an exact number but is nominally given at 1120 fps. When fired, the .22 rimfire bullet spends it's "flight time" in what is known as the "transonic region", which begins at around 70% below the speed of sound and continues to around 20% above it. In this region, any nominal change in velocity is accompanied by an exponential change in drag. To say it another way, you double the velocity, you increase drag by 4 times. The opposite happens as the bullet slows down; drag is reduced which means wind drift is also reduced. Who would have thought that slower is more efficient?
What I've written about pertains to .22 rimfire primarily and only a very few centerfire rounds and the reason is again, the "transonic zone" of muzzle velocity as it pertains to the speed of sound. The vast majority of centerfire bullet are hypersonic when the leave the barrel and only way down range do their bullets slow down into the transonic zone.
Here's a link to an article that should be required reading of everyone on this forum. It was written by one of our members, "griecke,"(another old guy).
Wind Drift.indd (sagecreekgus.com)
And as far as using a .22 as a trainer for centerfire, it would be nice if the .22 was a close approximation of the centerfire, but it's not a requirement. More importantly, you could use the .22 to work on your fundamentals and wind calling ability; those assets should readily transfer over to centerfire.