I think the mount interfering with gripping the pistol is a serious issue. On the other hand I cannot come up with a good solution for mounting a red dot on the slide of a P22. Then again polymer is used for the sights, the take down lever and the polymer grip is attached to the frame with two small pins.....so, certain plastics/polymers ( i don't know the difference) can certainly take the punishment of recoil and slide movement. .380, 9mm, etc. Much more punishing than a .22 cal round.
I think you might start with a photo of the stock pistol being gripped properly, hand included in the photo. Straight out from both sides. Now, how much room do you have to mount a red dot base, how would you design it, how would you attach it, is it possible to have suchand remove the slide without totally removing the mount which likely requires re zeroing.
My thought is to follow this path. The front pin is in a good location..the rear pin isn't. It is too close to the palm grip area. So, I will draw the outline of your concept so that it avoids my hand. Beef up the material around the front pin just a bit, move the bottom line rearward at the top of the trigger guard, move up over the serial number, move just rearward a bit for a specific purpose then upward in front of the safety levers raising the mounting surface to an adequate level. I'm not concerned with co-witnessing through the dot....the P22 isn't anywhere close to an adequate self defense firearm. But, I sure would like to be able to field strip the pistol without having to totally undo the existing zero. I'm not sure that is possible, only testing can determine that.
The concept I'm currently considering is to use the front mount pin hole to secure the front end of the mount as your concept shows. For the rear, I want it to snap down and lock in place on the polymer grip but be able to be lifted at the rear, pivoting upward on the front pin so that clearance is provided for removal of the slide. The mount will still be a saddle design and the left side will not necessarily match the right side. The catch can be something similar to that as used on the polymer take down lever or it might be a simple dimple drilled into the side of the polymer grip with a small ball cutter bit with your mount having a small, matching partial ball on the inside of each side of your mount. The frotn pin anchors the mount. The rear snaps down precisely in place at the rear.
Then we need to see how much clearance is required for the safety levers and the lifted slide as it moves forward for removal. These are simple measurements....but can a mount be designed that looks good and allows removal of the slide and will it lock down securely? We can draw it as a first step. If you can't draw it, you can't build it. 1917