Not an expert, only own one rimfire can. Did a lot of research and shot a few before deciding. To my ears, they all have about the same amount of sound reduction. Tone varies, bigger units are generally a tad quieter. I bought mine before the modular cans became popular. If they had been around then, I might have gone that way. Nice because you can alter the configuration- length/weight to suit your needs.
I went with a Surefire Ryder based on the following. Functions with all rimfire calibers, lightweight, 1” outside diameter and short overall length. Not the absolute quietest, but easy to clean and works well on all my rimfires, including pistols. In addition, I like that it minimally affects POI. Less than 1” at 50 yds on my rifles. I always shoot suppressed, but found that remarkable.
Over the last 2-3 years, there has been a lot of innovation in the industry. Anxious to see what will be revealed at Shot Show.
It is true that the rimfire suppressors are the gateway drug. Not sure that a centerfire rated can is best for rimfire use. Big and heavy in comparison to the rimfire models, especially for a pistol. Based on what is available now, I think a universal rimfire can and a universal centerfire rifle can cover things well. Centerfire pistols probably warrant a third can. My next suppressor will be a .30 cal can rated to .300 Win. That would cover all my centerfire rifles. Several good ones to choose from, not that much larger than a .223 can.
Anyway, enough of my ramblings. Addictive, fun and expensive hobby.