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I would not hesitate to take a shot at a coyote with a .22lr under 50 yards because I am very confident with my gun and I know how and where the ammo will hit.

The .22lr is actuallyu a very underrated cartridge and I KNOW that it will kill a coyote as long as you have the right ammo. I would suggest the use of a High Velocity Hollow Point such as a CCI Mini Mag 40gr. HP.

But the key is to PRACTICE!

I would say to go for it and just know when the distance is to far to effectivley take a coyote, you may have to pass it up.

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