My experience pretty much matches Jim's here ...
About 3 years ago I bought myself a 10/22LR, and the rest as they say is history. After a fun-filled year, I 'needed' something more so introduced Junior to Puff Daddy (10/22WMR).
Thanks to the LR, I was already a dedicated RFC 'lurker', and the Magnum forum pointed me in the direction of the Remington Premiers. Locating some turned out to be a bit of a problem because I'd dropped right into the 'taken-off-the-market' black-hole.
Eventually I managed to find TWO boxes of these hens-teeth ... one was GIVEN to me (with the words 'good luck' !), and the other one I purchased.
The first box (probably the older of the two), produced 2-3 squibs (failure-to-fire) per MAGAZINE. These could be ejected & reloaded, and maybe they'd fire the next time ... and maybe not.
The second box was better ... only 1 squib per magazine !
I've since bought several bricks of the 'all new & improved' Premiers and on the whole these are MUCH better, but ... I'm still getting an OCCASSIONAL squib (maybe 1 every 3-4 magazines).
And those all-important details ?
*polished action
*dri-lubed
*VQ exact edge
*VQ hammer kit
*standard firing pin (with a VQ on stand-by)
*cleaned after every session & stripped whenever the action starts to feel 'gritty'
Oh yeah ... AND I can shoot Win Supremes until the cows come home - before, after and DURING shooting the Premiers with ZERO squibs !