The Israeli police, believe it or not, are not allowed to carry their weapons with one in the pipe. As a result, they had to develop specialized quick-draw/load/aim/fire techniques. I was fortunate enough to have gone through a handgun course through ISI (Instinctive Shooting International - Taught by Hanan Yadin formerly of the IDF) The technique has merit. When I camp I carry an H&K USP. The first round is snake-shot, the next nine are either Hydrashocks or Hornady XTP's. I almost never carry with a round in the chamber. But I've proven to myself and anyone who cares to come to the range with me that I can draw, cock, aim and fire my .45 as quickly and accurately as I could drawing and firing a loaded firearm. (within about 30 feet, which is reasonable for CQB or backwoods situations. I don't know of any snake that can strike THAT far.) If you are lucky enough to get a warning from a snake, you have time to avoid it without having to shoot it. If you get bitten - it's kind of academic really, but shooting it may make you feel better - not to mention it may help to identify an anti-venom.
As far as one-handed operation. That was also something covered by the course. one handed magazine changes, reloads, etc...
ISI used to be in Texas, they had a website which I'm not sure is still up. They put on a great course though.