yes, if you get a well placed shot it most likely drop like a sack of hammers, but can you get a well placed shot in feild conditions? you have to remember that these sub inch groups are from a rest. if you can put 5-10 shots in a similar sized group sitting, or prone, as if you were actually shooting at a coyote, then you can shoot 'yotes with a .17 hmr, but i still wouldn't.