A local class three dealer has taken me out with him to test a couple of guns for customers. We tested two integrally suppressed 10/22's, and I didn't like them much at all. With this type rifle, you have to remember, they usually start with an inaccurate factory 10/22 barrel, then shorten it and maybe drill holes in it as well, so the accuracy is nothing to write home about. One was by Gemtech, and it was pretty worthless. It was supposed to slow high velocity ammo down to subsonic speed, and didn't. Best accuracy was obtained in this unit with high velocity ammo, but it wasn't quiet. Accuracy was poor at 50 yards with subsonic Eley target ammo.
We also tested an integrally suppressed 10/22 by SWR, and while better than the Gemtech in both noise suppression and accuracy, it still wasn't all that great. We then tested a .22LR Omega suppressor by SWR that threads on to the muzzle, and were VERY pleased with it. We tested it on a very accurate 10/22, and the groups both with and without the suppressor were just one hole at 50 yards with Eley. Point of impact didn't change at all, with the suppressor on or off, and it was very quiet. We also shot this suppressor on a Walther P22, and it worked great on that also. Based on this test, my dealer friend ordered several of the Omega's.
One nice thing about the suppressor that threads on the muzzle is that it's very versatile, and can be used on more than one rifle/pistol, while an integrally suppressed rifle or pistol is less versatile. Here is the link to SWR.
http://www.swrmfg.com/
Hope this helps,
John